Blar i forfatter "Kousha, Armin"

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    • Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant staphylococcus aureus 

      Kumaraswamy, Monika; Wiull, Kamilla; Joshi, Bishnu; Sakoulas, George; Kousha, Armin; Vaaje-Kolstad, Gustav; Johannessen, Mona; Hegstad, Kristin; Nizet, Victor; Askarian, Fatemeh (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-29)
      Methicillin-resistant Staphylococcus aureus (MRSA) has evolved numerous antimicrobial resistance mechanisms and is identified as a serious public health threat by the World Health Organization and U.S. Centers for Disease Control and Prevention. The glycopeptide vancomycin (VAN) remains a cornerstone of therapy for severe MRSA infections despite increasing reports of therapeutic failure in hospitalized ...

    • A case of vertebral coalescence and lateral line deformity in Hypophthalamichthys nobilis (Richardson, 1844) obtained from aquaculture activity in Iran 

      Jawad, Laith A.; Kousha, Armin (Journal article; Tidsskriftartikkel, 2011-10-31)
      Vertebral coalescence and malformation in the lateral line are reported in a specimen of cultured cyprinid fish <i>Hypophthalamichthys nobilis </i>. Severe vertebral fusion was observed and described. Lateral line showed unusual undulation in the trunk region. Genetic and epigenetic causes may be implicated in these anomalies.

    • Histological and bacteriological changes in intestine of beluga (Huso huso) following ex vivo exposure to bacterial strains 

      Salma, Wahida; Zhou, Zhigang; Wang, Wenwan; Askarian, Fatemeh; Kousha, Armin; Ebrahimi, Maryam Tajabadi; Myklebust, Reidar; Ringø, Einar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In the present study the intestinal sac method (ex vivo) was used to evaluate the interactions between lactic acid bacteria and staphylococci in the gastrointestinal (GI) tract of beluga (Huso huso). The distal intestine (DI) of beluga was exposed ex vivo to Staphylococcus aureus, Leuconostoc mesenteroides and Lactobacillus plantarum. Histological changes following bacterial exposure were assessed ...

    • Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia 

      Askarian, Fatemeh; Tsai, Chih-Ming; Cordara, Gabriele; Zurich, Raymond H.; Bjånes, Elisabet; Golten, Ole; Sørensen, Henrik Vinther; Kousha, Armin; Meier, Angela; Chikwati, Elvis Mashingaidze; Bruun, Jack-Ansgar; Ludviksen, Judith K; Choudhury, Biswa; Trieu, Desmond; Davis, Stanley; Edvardsen, Per Kristian Thorén; Mollnes, Tom Eirik; Liu, George Y.; Krengel, Ute; Conrad, Douglas J.; Vaaje-Kolstad, Gustav; Nizet, Victor (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)
      Pseudomonas aeruginosa (PA) CbpD belongs to the lytic polysaccharide monooxygenases (LPMOs), a family of enzymes that cleave chitin or related polysaccharides. Here, we demonstrate a virulence role of CbpD in PA pneumonia linked to impairment of host complement function and opsonophagocytic clearance. Following intratracheal challenge, a PA ΔCbpD mutant was more easily cleared and produced less ...

    • Staphylococcus aureus Membrane-derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models 

      Askarian, Fatemeh; Lapek Jr., John D.; Dongre, Mitesh; Tsai, Chih-Ming; Kumaraswamy, Monika; Kousha, Armin; Valderrama, J. Andrés; Ludviksen, Judith K; Cavanagh, Jorunn Pauline; Uchiyama, Satoshi; Mollnes, Tom Eirik; Gonzalez, David J.; Wai, Sun Nyunt; Victor, Nizet; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-20)
      <i>Staphylococcus aureus</i> produces membrane-derived vesicles (MVs), which share functional properties to outer membrane vesicles. Atomic force microscopy revealed that <i>S. aureus</i>-derived MVs are associated with the bacterial surface or released into the surrounding environment depending on bacterial growth conditions. By using a comparative proteomic approach, a total of 131 and 617 proteins ...